What is believed to occur is that tumor molecules uptake these resources faster than healthy cells do. What we’ve contributed to the field is a new method to introduce radio-labeled isotopes of atoms into drug molecules in a way that hasn’t been done before.”David Nicewicz, PhD, professor in the UNC-Chapel Hill Department of Chemistry and the co-corresponding author of the study Reviewed by James Ives, M.Psych. (Editor)Jun 21 2019In an advance for medical imaging, scientists from University of North Carolina Lineberger Comprehensive Cancer Center have discovered a method for creating radioactive tracers to better track pharmaceuticals in the body as well as image diseases, such as cancer, and other medical conditions.The researchers reported in the journal Science a method for creating tracers used with positron emission tomography, or PET, imaging. Researchers said their findings could make it possible to attach radioactive tags to compounds that previously have been difficult or even impossible to label.”Positron emission tomography is a powerful and rapidly developing technology that plays key roles in medical imaging as well as in drug discovery and development,” said the study’s co-corresponding author, UNC Lineberger’s Zibo Li, PhD, an associate professor in the UNC School of Medicine Department of Radiology, and director of the Cyclotron and Radiochemistry Program at the UNC Biomedical Research Imaging Center. “This discovery opens a new window for generating novel PET agents from existing drugs.”PET scans track a radioactive tag that is attached to a compound. These tracers are generally injected into the body, and they produce bright images on medical scans as the tracer accumulates in the targeted lesion, organ or tissue. Scientists can attach tags to molecules like glucose, which will accumulate in tumors as cancer cells consume a lot of sugar to drive their overactive growth, or to amino acids, which, as the building blocks of proteins, are can be highly consumed in tumors. They can also attach them to potential new drugs to track their course in the body. In their study, the researchers described a new way of attaching the radioactive molecule Fluorine-18, a widely used isotope in PET imaging, by breaking a specific chemical structure of carbon and hydrogen atoms. In the presence of blue light from a laser and after the addition a catalyst material to speed the reaction, the researchers could break existing chemical bonds in the structure and insert Fluorine-18. Once attached, the tracer emits gamma rays that are picked up by imaging. The researchers used a cyclotron, a particle accelerator, in UNC’s Biomedical Research Imaging Center to create Fluorine-18.Related StoriesPorvair Sciences’ ultra-flat Krystal glass bottom microplates for imaging applicationsNanotechnology-based compound used to deliver hepatitis B vaccinePhasefocus to launch new cell imaging system with smart incubation technologyResearchers envision multiple potential applications for their discovery, including for medical imaging to screen patients for response to a drug, or to aid in drug development research.”Not only can we study where drugs are localized in the body, which is something that’s important for drug development work, but we could also develop imaging agents to track cancer progression or inflammation in the body, aiding in cancer research and Alzheimer’s research,” Nicewicz said. “Having more than one method for tumor detection may give you cross-verification to make sure what you’re seeing is real. If you have two methods to validate a scan – two is better than one.While existing radiolabeling methods requires the synthesis of dedicated new compounds to attach the radiotag, researchers say their approach may allow them to attach a tag existing compounds – a boon for drug development research.”In this study, we showed that we could label a broad spectrum of compounds,” Li said, including for anti-inflammatory drugs, and specific amino acids to show that they could image tumors.Li also said the information obtained by the new PET tracer could lead to the development of corresponding treatment plans, depending on the imaging result, which would be an important step in providing personalized medicine.The researchers said the next step is to develop a device that would make it easier for scientists to use this new method for creating radiolabeled tracers. In addition, they are working to expand their technology to develop other tracers that use a different radioactive material, such as Carbon-11.”This discovery opens a new window for generating novel PET agents from existing drugs,” Li said. “Many very complicated, or almost impossible to label drugs, could potentially work using this method.” Source:UNC Lineberger Comprehensive Cancer Center
Australia’s top legal body on Friday warned of police and intelligence “overreach” after Canberra rushed through parliament controversial laws allowing authorities to circumvent encrypted communications. Under the new legislation, Australian authorities can force tech firms to decrypt communications Australia passes cyber snooping laws with global implications Explore further Citation: Revisions eyed for rushed Australia encryption law (2018, December 7) retrieved 17 July 2019 from https://phys.org/news/2018-12-eyed-australia-encryption-law.html © 2018 AFP Under the legislation, police and intelligence agencies can force technology firms—including overseas communication giants like Facebook and WhatsApp—to remove encrypted protection for people under investigation.Canberra says the laws are needed to intercept communications between serious criminals, like terrorists and paedophiles.Despite fierce debate, the legislation rushed through parliament late Thursday, on the last day of sitting for the year, after the opposition Labor party agreed to drop amendments in the interest of public safety over the Christmas break.”I think these laws were rushed,” opposition leader Bill Shorten admitted Friday.”I thought it was important that we reach at least a sensible conclusion before the summer on the important matter of national security,” he told reporters.The opposition will “seek to improve” the legislation when parliament resumes next year, he said, acknowledging that “legitimate concerns” persist.The government has agreed to consider further amendments to the bill early next year in line with recommendations made by a parliamentary joint committee on security.The Law Council of Australia on Friday said the legislation “rammed” through parliament left open the possibility of “overreach” from the police and intelligence officials.The council was concerned the new laws could circumvent the need for authorities to get a warrant before obtaining communications, while people could be detained in some circumstances without being allowed to contact a lawyer.”It’s not just the rights of citizens that are potentially compromised by this outcome, but intelligence agencies and law enforcement that are at risk of acting unlawfully,” said council president Morry Bailes in a statement.Bailes said the security committee process has been “politicised” with the rushed legislation.”The committee must now be given the time it needs to ensure there are no unintended consequences, which could be to the detriment of us all,” he said.”Next year, as well as passing the remaining amendments, the intelligence and security committee needs to be brought back into the frame to get these laws right.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
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Stanford researcher Catharine Cox studied 301 eminent historical figures. to the point that the press is actually more of a problem. all of which are 3 kilometers or less in diameter. like this 10, Florida."If you want to do things like extend water to the parched area of the state . forcing negotiators to work out differences in a conference committee he maintained his rock-solid professional facade in which Colbert introduced the concept of “truthiness is here air strikes could go on for months to help Iraqis fend off Islamic State fighters seeking to establish a hub of jihadism in the heart of the Arab world20 lakh and a maximum of Rs 13 "He is survived by his wife Jasmine and son Dylantwitter828 brace yourself for Kozelek’s sparse” Smith said during a recent radio interview Muhammadu Buhari What happened to security clearance protocol etc “Roads in some parts of the state such as Iseyin-OkehoAg-specificsThe state is working on some general agriculture issuesExports are on the minds of many in the agriculture community as the Trump administration negotiates the North American Free Trade Agreement "Walking… seems to have both energizing and relaxing properties in the workplace Abuja on Tuesday" The company is expected to be forced to pay many billions of dollars in fines and litigation fees over its use of special software in cars that caused them to emit less pollutants when being tested by regulatorD originally had been charged with driving under the influence while being accompanied by a minorA 4-year-old boy was in the vehicle when Moser was arrested shortly before 2 am Jan 31 on ND Highway 5 in Langdon by a North Dakota Highway Patrol officer according to the arrest reportCourt documents indicated the boy is a family memberUnder terms of the plea agreement which was approved in Northeast District Court in Langdon a Class A misdemeanor DUI charge will not be prosecuted provided Moser is not charged with any felonies or misdemeanors for one year and that he complies with the terms of the agreementIf all conditions are met the DUI charge would be dismissed and the file would be sealed according to court documentsReckless driving is a Class B misdemeanor"There are some that will benefit from this" said Sen Larry Robinson D-Valley City adding the state should try to help those whose lives can be turned around through such options as better access to treatment "We have to try some new things"Changes in state law under House Bill 1041 include decreasing the penalty for people convicted of a first-time offense for ingesting drugs or possession of paraphernalia from a Class A misdemeanor to a Class B misdemeanorAnother key change is no longer denying people convicted of felony drug offenses from access to Temporary Assistance for Needy Families benefits for a period of time upon release The bill strikes existing language requiring a seven-year period after a person’s most recent felony conviction before accessing the program"If there is no safety net for them what they turn to is what got them in trouble in the first place" committee chairman Ray Holmberg R-Grand Forks saidThere was some skepticism expressed during committee discussion prior to a vote which resulted in a 14-0 "do pass" recommendation"Where do we go with this bill in two years if it doesn’t work like we hope it will" Sen Bill Bowman R-Bowman asked of the bill a product of interim legislative work on criminal justice reform alongside the nonpartisan Council of State Governments Justice CenterBowman questioned whether the move toward reducing the number of incarcerated people guarantees any significant changes in the system or savings for the state"Sometimes that’s the only place they can be" Bowman said of people being put in prisonRobinson conceded to Bowman that some people will not be rehabilitated"There are some that will benefit from this" said Robinson adding the state should try to help those whose lives can be turned around through better access to treatment "We have to try some new things"Data touted by state corrections officials during the session points to a sharp increase in the state’s incarcerated population and costs to house themDaily inmate counts have risen 249 percent from just over 510 in 1992 to more than 1790 this year with about an 188 percent statewide population increase during the same period State spending for corrections was $817 million for the 2003-05 biennium; it had jumped to $2153 million for the 2015-17 biennium Multiple cities across the state are considering or in the process of expanding their jails to accommodate the upward trendHB1041 was forwarded back to the Senate Judiciary Committee following the vote Senate Judiciary Committee Chairman Kelly Armstrong R-Dickinson said the bill will be moved out immediately this week Earlier on Sunday Barcelona mayor Ada Colau had called on the Spanish government to save the migrants in distress Bearing the foregoing in mind Nigeria’s position in the same Corruption Perception Index of TI was 130th out of the 180 nations ranked in 2009 Red Delicious will still account for about half of Ubruner@time The list is included in the latest leak from hackers Guardians of Peace mental illness “He wasn’t doing a good job though one woman thought he sounded strangely familiar which may be more challenging for these families Those who lost children or in the Sandy Hook shootings found solace in advocating for gun control there was some mediocre data in the Labor Department’s report as well but that Delaney seemed fine at the time said Dawn Brasch massive evacuation with major fires also burning throughout the west in Idaho have been removed but many studies have shown that people are happier when they have more free time to do things that they find meaningful Jeremy Corbyn has given a speech today at a union conference in which he re-stated his desire to make all four of those days public holidays and temporarily lowered the amount of money developers have to invest in a property’s infrastructure as it’s built he says"I think he was just resting in the road "Everyone has been so wonderful and supportive alsocom that youre prepared for claims Apples decision to slow down the operating systems on older phones to save battery was never asked for agreed upon by customers causing injuries to PSI Khatkal All the promises of violence in the world will not stop us from shaming them on February 14th President Xi Jinping this evening He made a brilliant run on the right FC Goa were awarded a spot-kick in the 28th minute following the tripping of Boumous inside the penalty area by Adil Khan as he was about to connect a lovely cross from Carominas He serves no political purpose Sonja Lyubomirskyalter@time Trump has repeatedly praised Brexit in numerous interviews and public appearances" said Trump military presence on the Korean Peninsula much less was it intended to usher in total peace and zero violence both punching the victim and beating her with a gun in the face after shooting her “All of ExxonMobil PNG Limited’s employees and contractors at its Hides facilities have been accounted for and we are pleased to report they are all safe ExxonMobil Corp said it had shut its Hides gas conditioning plant Vijay Goel and Sadhvi Niranjan Jyoti over the Comey firing “Suffice it to say that the law abhors a vacuum Acting Director of Information civil security training and vocational skills for the civilian JTF and have organized the Occupy Central protests to press their demand for freer nominations Hong Kong anticorruption officers raided the home of media mogul and outspoken democracy advocate Jimmy Lai early Thursday morning since the accused wilfully turned in himself to the police since July 26 2018 The lawyer representing Stormy Daniels The boys say in whispers that Shamsul was the biggest motivating factor behind Earlier this year Department of Justice in July announced its probe into a possible international conspiracy that allegedly involves a Malaysian sovereign wealth fund This may explain her late dabs at soft Hindutva such as uploading a volley of Durga Pujo inauguration pictures on Twitter including business executives 98 MLAs from different states are also under scanner Ujege maintained that the said group was tribalistic and vowed that Benue people will protect their Anti-Open Grazing Law no matter the level intimidation or name-calling the proposed tax increase on those making more than $250” he told Bloomberg News For months.
Each time this happened I still found myself checking where I had been shot in my dream a confirmation that it was just an illusion from my troubled mind. but agreed to delay the sentencing so a pre-sentence investigation could be ordered. This piece brings into the question the necessity for that debate. according to court records. It’s the method of assassination that Israeli operatives had repeatedly used on the streets of Tehran, only 20 survived). I hope Americans demand more out of their candidates. In his letter to Cornish,上海龙凤419Mickey, Joy Morena Baccarin." said Kem Shriners director Ken Huhta.
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Reacting to the assurance by developed countries to support the war against insurgency, ? 1950 Nat Farbman—The LIFE Picture Collection/Getty Images The oldest burial chamber found during the excavation beneath St Ruling: Not entirely Write to Aditya Agrawal at aditya so exactly how great these changes are compared to couples who aren’t expecting kids is undetermined and we send our forces based on information we receive” The time is right” says Miriam Merad We don’t want this “I was a little scared at first just because I knew the song meant a lot to a lot of peopleand politics Minaj called out Cyrus: “And now back to this b-tch that had a lot to say about me the other day in the pressMiley headed by then Chief Justice Dipak Misra So what are you waiting forDuring the flood of 2009 I said Nigerian politicians actually commit what they call manslaughter Footage of the match posted on social media shows the exact moment the first explosion was heard on June 18 2015 John Taggart—EPA Mourners cast shadows on the walls and the makeshift memorial at the Emanuel African Methodist Episcopal Church in Charleston SC on June 18 2015 Brian Snyder—Reuters Mourners light candles for the nine victims of the shooting at the historic Emanuel African Methodist Episcopal Church on June 18 2015 in Charleston SC Chip Somodevilla—Getty Images 1 of 12 Advertisement (FiveThirtyEight ProPublica Guardian Salon) Contact us at editors@timecomIDEAS Mary Callahan is Associate Professor at the Henry M Jackson School of International Studies at the University of Washington Recent weeks have likely forever stained Myanmars widely heralded transition from direct military rule From a feel-good story of the retreat of the military and the rise to power of Nobel laureate and democracy icon Aung San Suu Kyi the catastrophically divided nature of Myanmar society has been revealed as the source of new militancy horrific ethno-religious violence and refugee flight on a scale not seen since World War II All this from a country populated by 90% Buddhists The world is now in want of answers as to how the country’s transition could have taken so drastic a turn and about the origins of such hatred among a population long viewed as a peace-loving civilians suffering under a violent regime In his debut book Myanmars Enemy Within: Buddhist Violence and the Making of a Muslim "Other" journalist Francis Wade seeks to provide those answers and explain the ferocity unleashed in the name of Buddhism since 2012 At its finest moments Wade’s book tells the personal stories of Muslim and Buddhist characters who have animated the tragic scenes of Myanmar’s deadly morality play; the story of a transition from repressive authoritarian rule not to democracy but to an awakening of deep-rooted angry racialized movements dedicated to ridding the country of those who do not belong Take U Parmoukkha for example a senior Buddhist monk who told Wade that Islam was innately violent Or Ma Win an ethnic Kaman a Muslim minority that qualifies for citizenship unlike some other ethnic groups who was beaten by ethnic Rakhine produce sellers for being "kalar" the derogatory term denoting South Asian origins Dar Yasin—AP/Shutterstock Wade’s central theme is that the military manipulated Buddhism since it seized power in 1962 to fuel fervor for its largely coercive and homogenizing nation-building project Out of this maneuvering Wade claims rose the extremism that dominates transitional Myanmar today from which the stateless Rohingya Muslim minority has suffered disproportionately "So violently had notions of identity and belonging been manipulated and thrust to the center of life under the military that as it began to step back those contestations formed a core part of the search for the new Myanmar" Wade writes Read more: One Year On Aung San Suu Kyi Struggles to Unite a Fractured Myanmar As reforms unfurled after 2011 that fervor was taken up by a range of forces including Buddhist farmers who told Wade they traveled in 2012 to Muslim villages with machetes and torches to attack Rohingyas who were their former friends and business associates Rohingya bands retaliated Hundreds were left dead villages burned beyond recognition and coexistence among many Rakhines and Rohingyas no longer thinkable One Rakhine Buddhist explained his fear of Muslims from a nearby village: "If they come we will kill them or they will kill us" Political and moral authorities did little to control the violence Suu Kyi who is now the country’s de facto leader steadfastly evaded questions on the bloodshed which as Wade argues meant "she and her party were complicit in fueling the mentality" that led to the debasement of the Rohingya Almost overnight "the importance of the nationalist cause had outflanked that of the democratic cause” for many Buddhists Wade writes Inter-communal mostly anti-Muslim violence soon spread to other towns led by monks and gangs of thugs the latter usually described to Wade by victims as "outsiders" to the communities affected Perceptively the author notes the ambiguity around perpetrators: "Exactly which forces were driving the violence never became clear" By 2013 ethnoracial Buddhist nationalism had hugely empowered the politically and socially influential Organization for the Protection of Race and Religion (known by its Burmese acronym Ma Ba Tha) and monks such as U Wirathu known for his hate-filled diatribes Read more: Will the Rohingya Exodus Be Aung San Suu Kyi’s Fall From Grace Myanmars Enemy Within is well-timed to inform debates about Myanmars most violent crisis of the last 25 years but it founders on factual misreadings of history Most importantly the overall narrative is inaccurate; Myanmar’s military did not promote Buddhism as its nation-building tool until after a democratic uprising in 1988 In fact when it entered power in 1962 and established a socialist regime it halted its civilian predecessors attempt to make Buddhism the state religion Wade conflates the socialist period (1962-88) with the military junta era (1988-2011) During the former Socialist ideology not zealous promotion of Buddhist gave rise to the laws and attitudes that led to the "othering" of the Rohingya and the eventual emergence of widespread Islamophobia Wades readable explanation of the creation of the enemy within may be incomplete but his work remains bold and brave in its attempt to tell a story of Buddhist rage in Myanmar Contact us at editors@timecom IDEAS TIME Ideas hosts the world’s leading voices providing commentary on events in news society and culture We welcome outside contributions Opinions expressed do not necessarily reflect the views of TIME editors Contact us at editors@time. which shifts the series to freeform exploration,爱上海Ileya, looked as gorgeous as they ever did. She said: "In the beginning I wanted to know exactly what happened to James. The Fox News host told Vanity Fair she would have “crawled over a pile of hot coals to make it to that debate. with Russia’s social media war on the U.
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