Technology company Arris has made its new E6000 co

first_imgTechnology company Arris has made its new E6000 converged edge router generally available.According to Arris, the E6000 has the capabilitity to realise the vision of the Comcast-sponsored CCAP initiative, which is designed to bring about a much denser headend infrastructure with the convergence of data, voice and video delivery.The device is currently configured as a dense CMTS, although Arris has demonstrated the delivery of converged services over a single F-connector at the most recent NCTA Cable Show.“We’re excited to declare the General Availability of the E6000 CER,” said Bruce McClelland, president, network and cloud global services, Arris. “Operators today are benefitting from the unrivaled efficiencies of the E6000 CER – in rack space, power consumption, cooling, advanced services and new applications.”last_img read more

Alex Daley Chief Technology Investment Strategist

first_img Alex Daley Chief Technology Investment Strategist Casey Research I sat down with Jim Rickards, author of many best-selling economics and investing books, including his latest, titled The Death of Money. In this exclusive interview, Jim shares his view on the changes in US foreign policy—the newly announced partnership with Iran to help fight ISIS and recent moves away from the petrodollar deal with Saudi Arabia—and what they mean for the dollar, gold, and investment markets in general. This interview just scratches the surface of the topics Jim covered in his speech at the most recent Casey Research Summit in San Antonio. You can grab a complete recording of that speech, and all 25 of the others, in the Summit Audio Collection, which is on sale with a juicy preorder discount for just a few more days.last_img read more

Recommended Link

first_imgRecommended Link • Gold is in a major slump…The chart below says it all.You can see that the price of gold has fallen 36% since 2011.That’s a major decline. But many gold mining stocks have fared even worse over the last few years… And that has dragged down major gold funds like the one Vanguard runs.In fact, VGPMX has lost about two-thirds of its value since 2011. The S&P 500, meanwhile, is up 130% over the same period.Because of this, I imagine many Vanguard clients were fed up. So, Vanguard is completely overhauling its precious metals fund.But if history’s any indication, this could be a sign that gold is close to a bottom. Let me explain…• Vanguard has been down this road before… In May 2001, it changed the name of its Vanguard Gold & Precious Metals Fund to simply the Vanguard Precious Metals Fund.It did so because gold had been an awful trade. It had fallen 15% over the previous five years. Sentiment toward the yellow metal was awful, just like it is today.So, Vanguard dropped “gold” from its fund’s name. And you can see what happened.Gold went on to enjoy a decade-long bull market. It rallied 615% over the next 10 years.Now, I can’t guarantee that the same thing will happen this time. But I will say this…Big funds like Vanguard don’t make moves like this when gold is at record highs. They do this when sentiment is in the toilet.And that can often be a sign that things can’t get any worse.In fact, Vanguard changed its fund’s name in 2001 within a month of gold bottoming. • Put another way, Vanguard’s decision could mean that gold is near “capitulation”…Capitulation means “surrender.” In the financial markets, this happens when the last sellers sell.And it’s usually characterized by panic selling, which is exactly what’s been happening with gold.In fact, gold is down 8% since the start of the year. The average gold stock, on the other hand, is down about 20% on the year.Vanguard’s decision could prove to be very bullish. But it’s certainly not the only reason to think gold is close to bottoming.• Speculators have never hated gold more than they do right now… We know this by looking at the Commitments of Traders (CoT) report.This is a report issued by the US Commodity Futures Trading Commission (CFTC). It shows the positions major traders have taken in certain securities and commodities.As of August 14, non-commercial traders—investors speculating on future price—were short (betting against) gold to the tune of 670 metric tonnes. According to market research team ANZ Research, that’s the biggest short position since the CFTC began collecting data in 1993.Not only that, investors have a net short position for the first time since 2001. This means that the value of total short bets exceeds the total long (bullish) bets.This tells us sentiment toward gold is extremely bearish.• This is exactly the kind of situation we like to bet against… You see, we’re contrarians here at Casey Research.When trades get extremely crowded, we like to take the opposite position. After all, buying an asset that other investors want nothing to do with is a proven way to make a ton of money.Take it from Doug Casey:You want to go where other people don’t go. That’s where you get the bargains.Everybody knows the old expression “buy low, sell high.” Well, when are the prices absolutely the lowest? When everybody else is afraid of the situation and, as the original Baron Rothschild put it, “blood is running in the streets.”• To take advantage of this big opportunity, I recommend betting on gold mining stocks…The easiest way to do this is with a fund like the VanEck Vectors Gold Miners ETF (GDX).But to make the biggest gains during the next gold bull market, you’ll need own the “best of breed” gold stocks.Unfortunately, most investors can’t tell the difference between a world-class miner and a crummy one.• That’s where we can help…At Casey Research, we have teams of research analysts who scour the globe in search of the world’s best mining companies.We even have an advisory dedicated to small mining stocks with massive upside potential called International Speculator. And editor Dave Forest has found the highest potential gold stocks today. They’re primed to rip higher when the gold market rebounds.If you’re not a subscriber, you can sign up for Dave’s International Speculator letter—and see his newest money-making idea—by clicking here.Regards,Justin SpittlerBudapest, HungaryAugust 28, 2018Reader MailbagToday, a reader responds to our recent Conversations With Casey, “Doug Casey on Why Somalia Shouldn’t Have an Army”…Who were the main countries that colonized and divided the continent of Africa leading to an exacerbation of culture, class, color and language issues? Any African leader that wanted a United States of Africa was assassinated. If there had been a United States of Africa we would be living in a different world.—AnonymousAs always, if you have any questions or suggestions for the Dispatch, send them to us right here.In Case You Missed It…Due to the scandalous acts of some CEOs with taxpayer funds, Congress just passed Bill S.2155.This bill has caused a domino effect in the markets that could mean thousands for investors—to the tune of $195 billion in “compensation checks.”Already, a growing number of Americans are collecting huge comp checks—some of them as big as $8,979… $9,587… and even $15,111, depending on the size of their position.It’s a new income stream that just might cover your entire retirement. Here’s Your Chance to Become a Pot Stock Millionaire as Marijuana Goes Mainstream…After five years of waiting on the sidelines, Big Tobacco… Big Alcohol… Big Pharma…and Big Banks are about to go all-in on legal pot. But they’re not going to grow their own weed or open up dispensaries. They’re going to go on a marijuana buying spree and buy up existing marijuana companies. And we’ve found three tiny pot companies that could be in the crosshairs of these corporate titans.Get all the details here. By Justin Spittler, editor, Casey Daily DispatchThe Vanguard Group has thrown in the towel on gold.And that has massive implications for the gold market. But not in the way most investors think.As you’re about to see, Vanguard’s decision could be extremely bullish for gold.I’ll tell you why in a second—and why it’s presenting the perfect kind of opportunity we look for at Casey Research. But let me first give you some background.• Vanguard is one of the world’s biggest money managers…It oversees $5 trillion in assets. That makes it too big to ignore.Last month, it made a major announcement. It said that it will change the name of its Vanguard Precious Metals and Mining Fund (VGPMX) to the Vanguard Global Capital Cycles Fund.More importantly, Vanguard will change what the fund holds. It will go from having 80% of its assets in mining stocks to just 25%. It will achieve this by adding stocks from industries like telecommunications and utilities to the mix.In other words, Vanguard is overhauling its precious metals fund…and changing it to a much more diversified fund.Now, I realize this sounds like terrible news for gold. But it could be one of the biggest buy signals for gold in years.More on that in a second. But let me first tell you why Vanguard did this. Recommended Link — Sneaky Politicians Don’t Want You to Know How They’re Snatching up to $11,334 Every Month for Life…But this former Wall Street hedge fund manager is going to tell you everything. Including how you can start collecting these payments too. Click here for all the details. —last_img read more

Keven Walgamott a real estate agent who lost his

first_imgKeven Walgamott, a real estate agent who lost his left hand and part of his arm in an electrical accident in 2002, got emotional when he was able to clasp his hands together and “feel” the space between his thumb and his index finger using a 3D-printed prosthetic hand in 2016.”That was the first time I ever felt anything in my left hand since my amputation,” Walgamott says. He got emotional a second time when he was able to grasp his wife’s hand and “feel” her touch, this time through a newly designed, experimental prosthetic hand that can be directed with the user’s mind.Walgamott was the sole volunteer for a 14-month study conducted by a multidisciplinary team based at the University of Utah, and also included collaborators from the University of Chicago and the Cleveland Clinic. The findings were published Wednesday in the journal Science Robotics.The research team adapted a commercially developed prosthetic named the “LUKE arm” — after the robotic hand the character Luke Skywalker got in the Star Wars film The Empire Strikes Back.The original LUKE arm had been designed to perform a variety of movements, but the Utah collaboration significantly improved it by figuring out how to mimic the way the human brain sends a signal to the hand to touch an object, and how the hand sends a signal back in response to touching it.”The nerves that communicate and control the hand and the nerves that send information back up to the brain still exist even after the hand has been amputated,” explains Jacob George, a doctoral student of biomedical engineering at the University of Utah and one of the lead authors of the study.The research team implanted electrodes in some of those nerves in Walgamott’s forearm and then recorded the signals that occurred when he thought of moving his hand to grab or touch an object. The prosthetic hand moved as commanded by Walgamott’s brain.Better feedback between prosthetic and brain”The whole ‘using feedback for prosthetics’ idea has been floating around for a while and people just haven’t shown whether or not it works,” says Sharlene Flesher, postdoctoral research associate at Stanford University, who also studies tactile feedback in prosthetic robotic limbs, but was not involved in this study. “The fact that they got everything to work is not a trivial result.”Other existing prosthetics can also convert brain signals into movement. But doing daily life tasks depends not only on our ability to grab objects but also on our ability to sense through touch what those objects are without looking at them.For instance, if you try holding an egg in your hand while blindfolded, you’ll likely know right away that you have to handle it carefully to avoid breaking it. This is because the nerves in your hand send signals to your brain that tell you — based on past experience and characteristics such as shape, texture and heft — that you’re holding an egg. But with most prosthetic hands you’d need visual clues to tell you how strongly you could grip the object to avoid dropping it or crushing it.The University of Utah researchers and their colleagues were able to restore Walgamott’s ability to “feel” what he was touching by providing stimuli through electrodes implanted in his arm; the information was quickly transmitted back up to the brain as if it were coming directly from the hand.By recovering some of his sense of touch in this way, Walgamott was able to precisely distinguish between large and small and soft and hard objects after roughly 10 seconds of handling them — even when his eyes or ears were covered.”We’re tapping into the same [mechanism] that’s used in my body and your body and everyone’s body, and we’re trying to just activate it in the way it would have normally been activated. So the sensations feel like they’re coming from their hand,” says George.Walgamott says the sensations he experienced with the robotic hand didn’t feel exactly the same as those from his other hand, but he still found the ability to touch, feel and manipulate fragile objects like grapes and eggs astounding.”Being able to pick up an egg without crushing it was a remarkable experience,” he says, and the skill translated to challenges he faces in daily life. Using the prosthetic in the lab, he was able to feed himself and load a pillow into a pillow case, and put on his wedding ring.”This study kind of pushes the importance of why we should have sensorized prosthetics,” says Flesher. Beyond all the remaining technical challenges, she says, getting insurance companies to recognize the importance of such devices will be a key hurdle to overcome.Insurance companies “think of it as a luxury,” Flesher says. “But [a sense of touch] really is so critical to how you control your arm.”Prosthetic hands that can restore one’s sense of touch are currently not available outside the lab — Walgamott participated in the study for 14 months, wearing the prosthetic device for only a few hours per session during that time, and only in the lab. It connected to his arm via surgically implanted wires that were removed when the 14-month-long study was completed.Using the device required a researcher’s direct supervision. For the LUKE Arm to be routinely usable at home, researchers would like to come up with a device that can be implanted inside the body, like a pacemaker. Though Utah companies are working on a wireless version of the device, it has only been tested in animals so far.George and his collaborators hope next to get approval from the Food and Drug Administration to begin testing their modified LUKE arm in larger groups of people, and in the participants’ own homes instead of the lab. They are now testing a prosthetic arm whose electronic controls can be strapped to the waist, which would make it easier for patients to use without supervision.’Phantom pain’ temporarily easedWalgamott’s burning phantom pain — a pain coming from the hand that is no longer there – also was reduced while his prosthetic hand was turned on.”[We are] recreating that sense of touch that they would normally be getting,” George explains. “When we start to do that, we think that we’re recreating the sense associated with that hand, [which] can kind of get rid of the pain.”Unfortunately, Walgamott says that the pain was reduced for only about an hour after taking the prosthetic off, and then the pain returned with the same intensity as before. He continues to feel that pain today.”Getting rid of phantom pain is one of the hopes,” a member of the research team told Walgamott during the experimental trial, according to a study transcript. “It’s not a promise. But if we restore sensory and motor function, then the prosthetic hand will become your hand, and the phantom will not have a place anymore.” Copyright 2019 NPR. To see more, visit https://www.npr.org.last_img read more

Android Lollipop is slowly making its way to more

first_imgAndroid Lollipop is slowly making its way to more and more users. In February, it was reported that only 1.6% were using Lollipop. But the operating system made it to 3.3% in March, and now Google has revealed that 5.4% of users are using either Android 5.0 or 5.1. Lollipop’s usage now surpasses Android Froyo, and is neck and neck with Android Ice Cream Sandwich.KitKat remains as the most used version of Android, making its way to 41.4% this month, compared to 40.9% last month.More information is available here.Xamarin expands its free student editionXamarin has announced that it is expanding its student edition to provide Visual Studio support. Xamarin for Students is a free offering that provides students with tools and resources for mobile app development. With it, students can create native Android and iOS apps using Xamarin and Visual Studio. “We are committed to developing the next generation of C# developers, giving more students the ability to publish amazing mobile experiences, and to bringing high-quality, high-performance consumer and enterprise apps to the masses,” wrote Joseph Hill, director of developer relations and cofounder, on Xamarin’s blog.HP realizes it can’t compete in the cloudHP is coming to terms that when it comes to cloud computing, it can’t complete with Amazon, Google and Microsoft, according to The New York Times.“We thought people would rent or buy computing from us,” Bill Hilf, head of cloud business at HP, told the Times. “It turns out that it makes no sense for us to go head to head.”The Times reported that HP is continuing to sell its servers, and is looking to build smaller cloud systems that would allow companies to use Amazon or Microsoft.last_img read more

When Is Vista not Vista When Its Mojave

first_img 2019 Entrepreneur 360 List When Is Vista not Vista? When It’s Mojave! 6 min read Apply Now » Add to Queue Brought to you by PCWorld Technology August 5, 2008center_img –shares Steve Bass The Microsofties are appealing to you to try Windows Vista. You’ll really, really like it, they insist. They’ve gone out of their way to prove to you that it’s a swell operating system, too, by creating a series of see-we-told-you-so videos.Microsoft’s ExperimentThe crew from Redmond dressed Windows Vista up in a flashy new box, called it Mojave, the next Microsoft OS, and foisted it upon–no, sorry, make that “introduced it to”–volunteers.Before the volunteers were shown Mojave, they were asked about Vista. Some said that they hated Vista, even though they’d never tried it. After seeing and playing with some of Vista, oops, Mojave’s features, most of the volunteers were impressed, with many of them oooh-ing and aaaah-ing.When the secret was revealed, most of the volunteers couldn’t wait to get their hands on a copy. One volunteer was nonplussed to hear that Mojave was actually Vista and asked, “Why is it faster?” In the experiment they used an HP Pavilion DV 2000 with 2GB of RAM–and I’m curious if that contributed to Vista’s great performance.If I had my way, I’d have Microsoft do another video, handing volunteers a copy of Mojave and asking them to install it on their existing PC or notebook. I wonder if their reactions would be quite so enthusiastic. BTW, here are Microsoft’s results.Vista ResourcesI still haven’t switched to Vista. I know I’ll do it eventually, but for the moment, my system’s running just fine. Nonetheless, I want you to know about a few Vista resources, just in case you’re using it–or, like me, thinking about the future.Answers to Vista Users’ Nagging Questions20 Vista Downloads to Tweak & Improve Your SystemWindows Vista: 15 Reasons to SwitchFarewell Vista, Hello XPWhat Does It Take to Get a PC With XP?Some of you may need the extra help that only a hefty resource book can provide. The book I recommend is Windows Vista Inside Out, Deluxe Edition (Microsoft Press; ISBN-10: 0735625247) by Ed Bott, Carl Siechert, and Craig Stinson. For under $40, you’ll get every Vista question answered and learn things about the OS that may improve your experience. It’s available on Amazon.com.Quick aside: Microsoft has confirmed it’s abandoning Windows. They won’t say when, but they have talked about what it’s going to look like. Read “Microsoft Prepares for End of Windows With Midori” and tell me if it makes sense to you.Fix Outlook’s Messy E-Mail QuotesOkay, enough about Vista. Now let’s pick on Outlook. Did you ever notice how well Outlook can mess up e-mail quotes? You know, the way it causes line breaks to make your e-mail look like hell?For the cost of a download you can make your Outlook e-mails look sharp and, more important, easy to read. The trick is Outlook-QuoteFix, a free add-in that takes out the tedium of fixing Outlook’s quoting style.Outlook-QuoteFix works perfectly in XP and with Outlook 98 through 2003; there’s a macro that makes it compatible with Outlook 2007. BTW, there’s also a version for Outlook Express.Easy Way to Reset Your Windows PasswordDo you ever forget your login password? Probably not, because it’s 1234. (LOL–just kidding. I know you use strong passwords.) Nearly two years ago, I told you how to find your passwords (go to “Find Old E-Mail Messages Quickly” and scroll to the “I forgot the password…” hassle). Unfortunately, that fix would have cost you $70, just enough to fill up your car’s gas tank.I have terrific news: PC Login Now gives you a fairly straightforward way to reset the Windows Administrator or user password in Windows Server 2008, 2003, Vista, and XP. Once you download the free ISO file, you burn it onto a CD and boot from it. The wizard talks you through the steps.One more thing before you leave: If you need to find the Product Key for any office product, read how to do it in “Five Smart Fixes for Dumb PC Annoyances.”This Week’s Roundup of Time WastersPeople Bucket, a physics-based game, is a total waste of time. The instructions are contradictory, because I have to cross the red line. But if you think about bouncing off walls, you may do okay.Draw Things is a simple personality test. Draw a house, a tree, or a person, and it will give you an insight into your “real personality.” It may even tell you if you should upgrade to Vista or switch to a Mac. [Thanks, John M.]If you like strategy games, take a shot at Desktop Tower Defense. Invaders are going to smash your desktop unless you’re smart enough to build a maze of artillery for them to follow–and get blasted to the bit bucket.How old is your brain? It’s a question you might not want answered. Unless you read Japanese, you’ll need some help. [Thanks, Shari K.]Here’s the procedure:Click StartWait for the 3, 2, 1 to disappear and then quickly memorize the position of the numbers on the screen.Click the circles in order from the smallest number to the largest number.The site tells you how old your brain is.You, or at least your character, Adam, can’t remember a thing. Do a couple of things right, survive an interrogation, and who knows, you might finish CDX next week.Some people collect coins. Others watch birds. These guys are into extreme catapulting.Steve Bass writes PC World’s monthly “Hassle-Free PC” column and is the author of “PC Annoyances, 2nd Edition: How to Fix the Most Annoying Things About Your Personal Computer,” available from Amazon.com. He also writes PC World’s daily Tips & Tweaks blog. Sign up to have Steve’s newsletter e-mailed to you each week. Comments or questions? Send Steve e-mail. Next Article The only list that measures privately-held company performance across multiple dimensions—not just revenue. Microsoft resorts to subterfuge to get people to try Windows Vista, as Steve Bass recently found. Plus, tips for Outlook and Windows passwords.last_img read more

Mozillas CEO Resigns in Wake of Criticism Over Stance on Gay Marriage

first_img –shares Free Webinar | July 31: Secrets to Running a Successful Family Business April 3, 2014 Next Article Add to Queue Guest Writer Image credit: Darcy Padilla Brendan Eich has stepped down as Mozilla’s CEO amid criticism over his donation to an anti-gay California marriage ballot measure back in 2008.Eich was appointed chief executive of the company just last week, a decision that caused an immediate and intense backlash, most notably from the dating site OKCupid. Visitors to the OKCupid website earlier this week were greeted with the message “Mozilla’s new CEO, Brendan Eich, is an opponent of equal rights for gay couples…We would therefore prefer that our users not use Mozilla software to access OKCupid.”Despite the intensifying criticism over his donation, just yesterday Eich told The Guardian that he would not be resign over his ‘private’ support for a gay marriage ban.But Mozilla has officially announced his departure this afternoon in a blog post.Related: 37 South Korean Bank Execs Offer to Resign Over Breach. Should Target Execs Follow Suit?”Mozilla prides itself on being held to a different standard and, this past week, we didn’t live up to it,” Mitchell Baker, Mozilla’s executive chairwoman, wrote. “We know why people are hurt and angry, and they are right: it’s because we haven’t stayed true to ourselves.”Baker went on to write that Eich had “chosen to step down from his role as CEO.” While figuring out how to simultaneously stand for both equality and freedom of speech is hard, she continued, “Our organizational culture reflects diversity and inclusiveness. We welcome contributions from everyone regardless of age, culture, ethnicity, gender, gender-identity, language, race, sexual orientation, geographical location and religious views. Mozilla supports equality for all.”The company said that what comes next for the organization’s leadership “is still being discussed.”Related: The Moz CEO’s Wonderfully Refreshing Reason for Stepping Down Opinions expressed by Entrepreneur contributors are their own.center_img 2 min read Brendan Eich Laura Entis Mozilla’s CEO Resigns in Wake of Criticism Over Stance on Gay Marriage Resignation Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now »last_img read more

Using molecular targeting approach to kill melanoma cells

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 27 2018In 1960, scientists described the “Philadelphia chromosome” that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic change. It was the dawn of genetically-targeted treatments against cancer and it seemed as if many cancers would fall to a similar strategy: Find a genetic difference between cancer cells and healthy cells, and then develop a drug to target this difference. Of course, rarely has it proved that easy. It’s difficult to find a genetic difference common to all cells within a single cancer, and many of these differences are impossible to target with existing drug strategies. Often this seemingly simple gene/drug pairing doesn’t work.Then again, sometimes it does.A University of Colorado Cancer Center study published in the journal Science Translational Medicine describes a genetic change common to 80 percent of human melanomas, the most deadly form of skin cancer, and also describes a molecule that seeks out cells marked by this genetic change. The current study attaches a radioactive label to the targeting molecule and uses positron emission tomography (PET) imaging to show that the radiolabeled molecule does, in fact, seek out and bind to melanoma cells. Using a similar approach, it may be possible to not only image these cells, but to attach therapy to this targeting molecule to kill these melanoma cells.The work starts with a protein called melanocortin-1 receptor (MC1R), which is involved in determining skin and hair color, but which is also found at a higher level on the surface of more than 80 percent of human melanomas. The current study describes a “peptide” that specifically binds to MC1R. If MC1R is a lock, then the peptide 68Ga-DOTA-GGNle-CycMSHhex is the key that fits it. In this case, researchers attached an imaging radionuclide to this peptide – the combination of peptide and radionuclide found, bound, and “lit up” melanoma metastases, allowing researchers to image these melanoma cells.The success of this molecular targeting approach suggests the possibility of using the peptide as a delivery vehicle to transport a therapeutic radionuclide directly to melanoma cells marked with MC1Rs for therapy.Related StoriesUAMS-developed noninvasive device detects melanoma in earliest stagesBacteria from seawater provide new leads to treat malignant melanomaNew clinical genomic testing helps identify mutations that drive childhood melanoma”Basically, we attach the imaging radionuclide to the peptide, then the radiolabeled peptide finds MC1Rs on the melanoma through blood circulation, allowing us to use a PET machine to gather the signals from the radiolabeled peptide for melanoma imaging. It’s a very sensitive way to see melanoma,” says Yubin Miao, PhD, investigator at CU Cancer Center and Director of Radiopharmaceutical Science at the Radiology of CU School of Medicine.In addition, researchers were able to replace the radiolabel with a fluorescent one to generate a new MC1R-targeting fluorescence imaging probe (called Cy5.5-GGNle-CycMSHhex). The current study shows that the fluorescent probe binds and stains MC1Rs on melanoma cells and lesions. Miao sees that the combination of these two approaches – one radiolabeled and one fluorescent – may potentially improve surgical outcomes for melanoma via imaging-guided surgery.He also sees the potential to use a similar strategy as a personalized therapeutic approach for patients with melanoma metastases high in MC1Rs, especially for brain metastases.”Approximately 60 percent of patients with metastatic melanoma develop brain metastases during the course of their disease. Patients with brain metastases have much shorter life expectancies than patients without brain metastases. Our study shows that the MC1R continues to mark melanoma cells even after these cells metastasize from the site of origin to brain, and this peptide can bind to MC1Rs in melanoma brain metastases. One potential application for this technology is to use our imaging systems to identify MC1R-postive melanoma tumors and then treat these lesions with therapies delivered by this peptide,” Miao says.For now, the current study demonstrates the first-in-human ability to image melanoma metastases using the group’s radiolabeled peptide. With more funding and collaboration, the Miao group hopes to explore the therapeutic potential in the near future. Source:https://coloradocancerblogs.org/targeting-mc1r-in-metastatic-melanoma/last_img read more

Mathematicians propose to improve cellular network coverage by using UAVs

first_imgUAVs providing network coverage. Credit: Allen Dressen RUDN University mathematicians have simulated the work of a cellular network and modeled the use of unmanned aerial vehicles as additional transmitters. Most of the available communication systems have flat coverage and do not take into account the difference in altitude, which results in the appearance of the so-called “blind” zones. Flying drones could solve this issue. The work is published in the journal IEEE Transactions on Vehicular Technology. Citation: Mathematicians propose to improve cellular network coverage by using UAVs (2018, September 19) retrieved 17 July 2019 from https://phys.org/news/2018-09-mathematicians-cellular-network-coverage-uavs.html Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. “Drones have become a promising tool for a variety of applications—from wireless information transfer to delivery of goods. They are of interest as flying access points for cellular network users, and as mobile signal amplifiers. We simulate a communication system using drones, taking into account many features of the real-life situation, including random distances between simulation objects (from drones to users, for instance). We model the system in three dimensions, i.e. in 3-D format, which significantly improves the accuracy of modeling in comparison with the known models. The approach itself—the use of unmanned aerial vehicles—will increase the coverage of the cellular network by about 40 percent,” says Konstantin Samuylov, head of Applied Informatics and Probability Theory Department, RUDN University.Cellular communication, which is used by mobile phones, is based on the transmission of information via radio waves. To create a seamless network, the coverage area (for example, a city) is divided into overlapping units, or cells, and a separate base station operates in each of them. These stations are capable of both transmitting and receiving radio waves from mobile phones. The main drawback is that the emissions from the base stations are flat (two-dimensional). That is why quality of communication varies at different heights. Mathematicians presented a model in which flying unmanned drones would serve as additional receivers-transmitters of radio waves and cover areas beyond the reach of conventional base stations. This will significantly improve the quality and reliability of the service.Employing the calculations of stochastic geometry (a discipline at the junction of geometry and probability theory), the scientists built a three-dimensional model of a cellular network that uses unmanned aerial vehicles. They differ from stationary base stations because they use directional millimeter-wave emissions with wider frequencies and higher energy (by two orders of magnitude). Such waves are safe for humans and provide an opportunity to significantly increase the data transfer speed. This is another factor that makes the use of unmanned aerial vehicles effective.As the authors of the paper note, the main feature of the 3-D model is that it takes into account the fact that the receiver-transmitters of the drone and the user are at different heights. This increases the accuracy of the calculations when estimating possible interference. The calculations showed that the interaction between the drones and the user would be most effective if the signal of the UAV is at close to a right angle. In this case, it meets fewer obstacles in the form of buildings and people on its way.The research was carried out by the staff and students of RUDN University together with the colleagues from the Technological University of Tampere (Finland). More information: Roman Kovalchukov et al. Analyzing Effects of Directionality and Random Heights in Drone-based mmWave Communication, IEEE Transactions on Vehicular Technology (2018). DOI: 10.1109/TVT.2018.2857215 Provided by RUDN University Mathematicians suggest exchanging wireless energy for data collected by sensors in mobile deviceslast_img read more

New California internet neutrality law sparks US lawsuit

first_img © 2018 The Associated Press. All rights reserved. In this Dec. 7, 2017, file photo, demonstrators rally in support of net neutrality outside a Verizon store in New York. California Gov. Jerry Brown has approved the nation’s strongest net neutrality law, prompting an immediate lawsuit by the Trump administration and opening the next phase in the battle over regulating the internet. (AP Photo/Mary Altaffer, File) Explore further In this Dec. 14, 2017, file photo, a sign with an emoji reads “Don’t take net neutrality away” is posted outside the Federal Communications Commission (FCC), in Washington. California Gov. Jerry Brown has approved the nation’s strongest net neutrality law, prompting an immediate lawsuit by the Trump administration and opening the next phase in the battle over regulating the internet. (AP Photo/Carolyn Kaster, File) Net neutrality advocates worry that without rules, internet providers could create fast lanes and slow lanes that favor their own sites and apps or make it harder for consumers to see content from competitors.That could limit consumer choice or shut out upstart companies that can’t afford to buy access to the fast lane, critics say.The new law also bans some forms of “zero rating,” in which internet providers don’t count certain content against a monthly data cap. A company could not, for example, exempt video streams produced by the company’s own subsidiaries and partners unless it zero rates all video streams.Oregon, Washington and Vermont have approved legislation related to net neutrality, but California’s measure is seen as the most comprehensive attempt to codify the principle in a way that might survive a likely court challenge. An identical bill was introduced in New York. “Rather than 50 states stepping in with their own conflicting open internet solutions, we need Congress to step up with a national framework for the whole internet ecosystem and resolve this issue once and for all,” the group said in a Sunday statement. In this June 29, 2018, file photo, California Gov. Jerry Brown speaks at a forum in Sacramento, Calif. Brown signed the nation’s toughest net neutrality measure Sunday, Sept. 30, requiring internet providers to maintain a level playing field online. (AP Photo/Rich Pedroncelli, File) Advocates of net neutrality hope California’s law, which Brown signed Sunday to stop internet providers from favoring certain content or websites, will push Congress to enact national rules or encourage other states to create their own.However, the U.S. Department of Justice quickly moved to halt the law from taking effect, arguing that it creates burdensome, anti-consumer requirements that go against the federal government’s approach to deregulating the internet.”Once again the California Legislature has enacted an extreme and illegal state law attempting to frustrate federal policy,” U.S. Attorney General Jeff Sessions said in a statement.The Federal Communications Commission repealed Obama-era rules last year that prevented internet companies from exercising more control over what people watch and see on the internet.The neutrality law is the latest example of California, ground zero of the global technology industry, attempting to drive public policy outside its borders and rebuff President Donald Trump’s agenda. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: New California internet neutrality law sparks US lawsuit (2018, October 1) retrieved 17 July 2019 from https://phys.org/news/2018-10-california-internet-neutrality-law-lawsuit.html Brown did not explain his reasons for signing the bill or comment on the federal lawsuit Sunday night.Supporters of the new law cheered it as a win for internet freedom. It is set to take effect Jan. 1.”This is a historic day for California. A free and open internet is a cornerstone of 21st century life: our democracy, our economy, our health care and public safety systems, and day-to-day activities,” said Democratic Sen. Scott Wiener, the law’s author.It prohibits internet providers from blocking or slowing data based on content or from favoring websites or video streams from companies that pay extra.Telecommunications companies lobbied hard to kill it or water it down, saying it would lead to higher internet and cellphone bills and discourage investments in faster internet. They say it’s unrealistic to expect them to comply with internet regulations that differ from state to state.USTelecom, a telecommunications trade group, said California writing its own rules will create problems. California net neutrality bill clears key hurdle California Gov. Jerry Brown has approved the nation’s strongest net neutrality law, prompting an immediate lawsuit by the Trump administration and opening the next phase in the battle over regulating the internet.last_img read more

US blocks more Chinese tech firms on national security concerns

first_img © 2019 AFP Citation: US blocks more Chinese tech firms on national security concerns (2019, June 22) retrieved 17 July 2019 from https://phys.org/news/2019-06-blocks-chinese-tech-firms-national.html Trade tensions between the world’s top two economies have spilled over into the tech sector, with Trump’s administration moving to essentially ban Chinese tech firm Huawei from the huge US market on security grounds The notice targets Sugon—a prominent Chinese supercomputer manufacturer—along with three of its microchip subsidiaries and a computing institute owned by the People’s Liberation Army.All of the entities will be effectively barred from obtaining US technology after the government determined they were “acting contrary to the national security or foreign policy interests of the United States.”Trade tensions between the world’s top two economies have spilled over into the tech sector in recent months, with Trump’s administration moving to essentially ban Chinese tech firm Huawei from the huge US market on security grounds.In May, it added Huawei to an “entity list” of companies barred from receiving US-made components without permission from Washington, though the company was granted a 90-day reprieve.Facebook and Google have since both announced they will move to cut off Huawei in order to comply with the US sanctions, further isolating the Chinese tech giant.Beijing has responded with threats to release its own blacklist of “unreliable” foreign companies and individuals that appears aimed at pressuring foreign companies to maintain commercial relations with Huawei.Earlier this month, Beijing summoned executives from American firms Dell and Microsoft and South Korea’s Samsung, among others, to warn them that any moves to ramp down their businesses in China may lead to retaliation, The New York Times reported.Trump and his Chinese counterpart Xi are set to meet next week on the sidelines of the G20 summit in Japan. China to set up system to safeguard technology securitycenter_img Explore further The US Commerce Department blacklisted five Chinese tech entities Friday in a new move against Beijing’s supercomputing industry likely to raise tensions ahead of a meeting between President Trump and Xi Jinping next week. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Lok Sabha clears bill to set up central tribal universities in Andhra

first_img Next Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 17:57 IST The two universities will increase access and quality of higher education. (Image for representation: Reuters)A Bill to set up a central university and a tribal university in Andhra Pradesh was passed by the Lok Sabha on Friday.Moving the Central Universities (Amendment) Bill, 2019 for passage, HRD Minister Ramesh Pokhriyal Nishank said the government has alloted Rs 450 crore for the central university and Rs 420 crore for the central tribal unversity.Currently these two universiites are functioning in temporary facilities in Anantpur and Vijayanagaram respectively.He said the Modi government has given Andhra Pradesh two universities and seven institutions of importance.Stating that at present the education department has a budget of Rs 1.25 lakh crore, he said the government is moving at a fast pace in the area of education.It has put the education sector under focus to ensure all round development, he said.To a query, he said vacant posts in all central education institutions will be filled up in the next few months.According to the Central Universities (Amendment) Bill, 2019, the two universities will increase access and quality of higher education and also promote avenues of higher education for the people of the state.The Tribal University will provide instructional and research facilities in tribal art, culture and customs and advancement in technology to the tribal population of India.At present, there is no central university in Andhra Pradesh while other states, except Goa, have one or more such institution.Setting up a central university and a central tribal university in Andhra Pradesh is obligatory under the Andhra Pradesh Reorganisation Act, 2014 for creation of Telangana.Participating in the discussion, K Suresh (Cong) said that the bill has not mentioned about detailed funding mechanism and funding of universities have remained an issue in the country.There is also no mention about curriculum and administration of these two universities in the bill, he said.He added that it was also not mentioned whether tribals would get reservation in the central tribal unversity.”The NDA government is known for reducing funding for central universities,” he said, adding there are several vacancies in different universities not yet filled.Rajiv Pratap Rudy (BJP) took a swipe at the TDP for questioning the intentions of Prime Minister Narendra Modi.TDP, a former ally of NDA, currently has only 3 Lok Sabha members at against 15 in 2014.He also expressed concern over rise in number of students in coaching centres.Coaching centres have become a big business in the country, he said, adding as per a study, out of four students, one is going for tuitions.He demanded granting of central university status to Patna University and Jai Prakash University in Chhapra.Saugata Roy (TMC) said the Delhi University is one of the best in the country. He said unless the number of seats is increased in the university the “terrible pressure” would stay.He said the cut off marks for its enrollment are touching 95 per cent, 98 per cent and 99 per cent.He also alleged that the Nagpur University is including history of RSS in its curriculum.”Let the university not work on RSS agenda but on national agenda,” he added.Lavu Sri Krishna (YSRCP) said that a central university should attract students and faculty from all parts of the country.”Unless we strengthen the tribal schools, the central university will not be meaningful,” he said.Rahul Shewale (SS) demanded more funds for a campus in the Mumbai University and filling of all vacant vacancies.Also Read | 1,513 farmers committed suicide in Andhra Pradesh between 2014-19: CM Jagan ReddyAlso Watch | Karnataka: Here’s how this Indo-Israel collaboration is helping farmers in Kolar districtFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Tags :Follow Andhra PradeshFollow Universities Lok Sabha clears bill to set up central, tribal universities in Andhra PradeshMoving the Central Universities (Amendment) Bill, 2019 for passage, HRD Minister Ramesh Pokhriyal Nishank said the government has alloted Rs 450 crore for the central university and Rs 420 crore for the central tribal unversity.advertisementlast_img read more

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Miika and scores of other children spent upwards of a year in foster homes while officials debated their status." she points out calmly. where a van drove into pedestrians on London Bridge before three men started stabbing people in nearby bars and restaurants. Yes, sometimes, people have reacted differently. "Im ready, but just who exactly is this mystery woman? read more

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